| #1Goldflower Cannabis Dispensary Fort PierceSt. Lucie County | 42.2%289 of 681 squares | 4.7best 1 | 4.9 | 762 |
| #2Green Dragon Dispensary Fort PierceFort Pierce · St. Lucie County | 31.2%214 of 681 squares | 6.3best 1 | 4.9 | 445 |
| #3RISE DispensarySt. Lucie County | 21.9%150 of 681 squares | 6.1best 1 | 4.9 | 66 |
| #4Sanctuary Cannabis Fort Pierce DispensarySt. Lucie County | 20.0%137 of 681 squares | 7.7best 1 | 4.8 | 1,319 |
| #5Curaleaf Dispensary Jensen BeachJensen Beach · Martin County | 19.3%132 of 681 squares | 10.2best 1 | 4.8 | 807 |
| #6AYR Cannabis Dispensary Port St. LuciePort St. Lucie · St. Lucie County | 18.5%127 of 681 squares | 10.9best 1 | 4.6 | 964 |
| #7Cookies Port St. Lucie DispensarySt. Lucie County | 16.6%113 of 681 squares | 7.9best 1 | 4.9 | 1,325 |
| #8AYR Cannabis Dispensary Fort PierceFort Pierce · St. Lucie County | 14.8%101 of 681 squares | 9.4best 1 | 4.9 | 894 |
| #9Trulieve Port Saint Lucie East DispensarySt. Lucie County | 13.8%94 of 681 squares | 9.7best 1 | 4.4 | 458 |
| #10Curaleaf Dispensary Port Saint LucieSt. Lucie County | 13.1%89 of 681 squares | 9.0best 1 | 4.7 | 265 |
| #11Sunnyside Medical Cannabis Dispensary - Port St. LucieSt. Lucie County | 11.5%80 of 681 squares | 9.7best 1 | 4.9 | 1,609 |
| #12Trulieve Fort Pierce DispensarySt. Lucie County | 10.4%73 of 681 squares | 7.3best 2 | 4.6 | 819 |
| #13Trulieve Stuart DispensaryStuart · Martin County | 8.7%59 of 681 squares | 10.2best 1 | 4.6 | 1,028 |
| #14Trulieve Port Saint Lucie DispensaryPort St. Lucie · St. Lucie County | 7.2%49 of 681 squares | 10.9best 1 | 4.3 | 918 |
| #15MÜV Cannabis DispensarySt. Lucie County | 6.6%45 of 681 squares | 12.1best 1 | 4.9 | 1,351 |
| #16MÜV Cannabis DispensarySt. Lucie County | 4.8%34 of 681 squares | 7.6best 1 | 4.9 | 508 |
| #17MMJ Health - Port St LucieSt. Lucie County | 4.7%32 of 681 squares | 12.1best 1 | 4.7 | 735 |
| #18Southern Comfort MMJ ClinicSt. Lucie County | 4.0%27 of 681 squares | 13.5best 1 | 4.9 | 720 |
| #19Sunburn Cannabis Stuart DispensaryMartin County | 3.9%28 of 681 squares | 11.4best 2 | 4.8 | 194 |
| #20Surterra WellnessPort St. Lucie · St. Lucie County | 3.7%25 of 681 squares | 12.4best 1 | 4.3 | 340 |
| #21Rooted Zen HealthcareSt. Lucie County | 3.1%21 of 681 squares | 10.9best 1 | 5.0 | 281 |
| #22Curaleaf Dispensary Fort PierceFort Pierce · St. Lucie County | 2.4%17 of 681 squares | 9.2best 1 | 4.6 | 805 |
| #23Angelic LiftSt. Lucie County | 2.1%14 of 681 squares | 11.3best 1 | 4.9 | 180 |
| #24Med Leaf, LLCSt. Lucie County | 1.8%12 of 681 squares | 12.3best 2 | 4.2 | 30 |
| #25Mr. Smoke Port St LucieSt. Lucie County | 1.5%10 of 681 squares | 11.3best 1 | 4.8 | 576 |
| #26Miracle Leaf Medical Marijuana DoctorSt. Lucie County | 1.0%7 of 681 squares | 11.6best 1 | 4.8 | 133 |
| #27CannaMDSt. Lucie County | 1.0%7 of 681 squares | 10.9best 2 | 4.9 | 113 |
| #28SMOKES SMOKE SHOPSt. Lucie County | 1.0%7 of 681 squares | 7.9best 2 | 4.9 | 339 |
| #29Trilogy Medicinal - Port St Lucie Medical Marijuana Doctor and Cannabis CardsSt. Lucie County | 1.0%7 of 681 squares | 11.5best 2 | 5.0 | 644 |
| #30SMOKIES SMOKE SHOPSt. Lucie County | 0.9%6 of 681 squares | 8.7best 1 | 4.8 | 280 |
| #31Planet 13 Neighborhood Dispensary StuartMartin County | 0.8%6 of 681 squares | 10.9best 2 | 4.9 | 391 |
| #32DoctorsRxSt. Lucie County | 0.7%5 of 681 squares | 10.3best 1 | 5.0 | 28 |
| #33Medical Marijuana Treatment Clinics of FloridaSt. Lucie County | 0.7%5 of 681 squares | 10.9best 3 | 4.9 | 191 |
| #341ST SMOKE SHOPSt. Lucie County | 0.6%4 of 681 squares | 9.7best 2 | 4.8 | 47 |
| #35Hemp StationSt. Lucie County | 0.6%4 of 681 squares | 12.6best 2 | 4.5 | 33 |
| #36Hemp HavenSt. Lucie County | 0.6%4 of 681 squares | 10.5best 3 | 5.0 | 55 |
| #37High ExpectationsSt. Lucie County | 0.6%4 of 681 squares | 11.3best 3 | 4.6 | 119 |
| #38The Hippie HutSt. Lucie County | 0.4%3 of 681 squares | 13.1best 2 | 4.6 | 44 |
| #39Habibiz Smoke Shop Down Town Fort PierceSt. Lucie County | 0.3%2 of 681 squares | 13.7best 1 | 5.0 | 260 |
| #40Vero Beach 420 DoctorIndian River County | 0.3%2 of 681 squares | 10.4best 2 | 4.7 | 95 |
| #41PSL SMOKE & VAPESt. Lucie County | 0.3%2 of 681 squares | 10.0best 2 | 4.4 | 61 |
| #42Medicus Cannabus: Dr. James Hill II, DOSt. Lucie County | 0.3%2 of 681 squares | 11.7best 2 | 4.0 | 40 |
| #43ROYAL TOBACCO AND VAPESt. Lucie County | 0.3%2 of 681 squares | 12.4best 3 | 4.8 | 234 |
| #44Peace PipeSt. Lucie County | 0.2%2 of 681 squares | 13.1best 1 | 4.7 | 110 |
| #45Green Dragon Dispensary - StuartStuart · Martin County | 0.1%1 of 681 squares | 12.0best 3 | 4.9 | 613 |
| #46Yoga SmokesSt. Lucie County | 0.1%1 of 681 squares | 9.4best 3 | 4.8 | 82 |
| #47Lucid Dreamz Smoke ShopIndian River County | 0.1%1 of 681 squares | 11.7best 3 | 4.9 | 512 |
| #48Trulieve Vero Beach DispensaryVero Beach · Indian River County | 0.1%1 of 681 squares | 9.4best 3 | 4.3 | 931 |
| #49Namaste Kava & BotanicalsSt. Lucie County | 0.1%1 of 681 squares | 12.9best 3 | 4.5 | 103 |
| #50LEAFORIA SMOKE SHOPSt. Lucie County | <0.1%1 of 681 squares | 3.0best 3 | 4.9 | 22 |