| #1RISE DispensarySt. Lucie County | 33.5%118 of 350 squares | 5.4best 1 | 4.9 | 66 |
| #2Curaleaf Dispensary Port Saint LucieSt. Lucie County | 27.1%95 of 350 squares | 8.7best 1 | 4.7 | 265 |
| #3Curaleaf Dispensary Jensen BeachJensen Beach · Martin County | 22.3%78 of 350 squares | 9.4best 1 | 4.8 | 807 |
| #4Cookies Port St. Lucie DispensarySt. Lucie County | 20.9%73 of 350 squares | 7.6best 1 | 4.9 | 1,325 |
| #5AYR Cannabis Dispensary Port St. LuciePort St. Lucie · St. Lucie County | 18.4%65 of 350 squares | 10.5best 1 | 4.6 | 964 |
| #6Sanctuary Cannabis Fort Pierce DispensarySt. Lucie County | 18.3%65 of 350 squares | 8.9best 1 | 4.8 | 1,319 |
| #7Goldflower Cannabis Dispensary Fort PierceSt. Lucie County | 16.0%57 of 350 squares | 6.3best 1 | 4.9 | 762 |
| #8Trulieve Port Saint Lucie DispensaryPort St. Lucie · St. Lucie County | 14.9%52 of 350 squares | 9.2best 1 | 4.3 | 918 |
| #9Sunnyside Medical Cannabis Dispensary - Port St. LucieSt. Lucie County | 14.7%53 of 350 squares | 9.6best 1 | 4.9 | 1,609 |
| #10Trulieve Port Saint Lucie East DispensarySt. Lucie County | 14.6%51 of 350 squares | 10.2best 1 | 4.4 | 458 |
| #11Trulieve Stuart DispensaryStuart · Martin County | 14.4%51 of 350 squares | 9.4best 1 | 4.6 | 1,028 |
| #12MÜV Cannabis DispensarySt. Lucie County | 11.1%39 of 350 squares | 10.7best 1 | 4.9 | 1,351 |
| #13Green Dragon Dispensary - StuartStuart · Martin County | 6.7%24 of 350 squares | 9.8best 1 | 4.9 | 613 |
| #14MMJ Health - Port St LucieSt. Lucie County | 6.3%22 of 350 squares | 12.5best 1 | 4.7 | 735 |
| #15Sunburn Cannabis Stuart DispensaryMartin County | 5.8%22 of 350 squares | 9.9best 1 | 4.8 | 194 |
| #16Southern Comfort MMJ ClinicSt. Lucie County | 5.7%20 of 350 squares | 13.0best 1 | 4.9 | 720 |
| #17Green Dragon Dispensary Fort PierceFort Pierce · St. Lucie County | 5.6%21 of 350 squares | 9.2best 2 | 4.9 | 445 |
| #18Surterra WellnessPort St. Lucie · St. Lucie County | 5.1%18 of 350 squares | 11.3best 1 | 4.3 | 340 |
| #19Rooted Zen HealthcareSt. Lucie County | 4.6%16 of 350 squares | 10.9best 1 | 5.0 | 281 |
| #20Angelic LiftSt. Lucie County | 3.4%12 of 350 squares | 11.3best 1 | 4.9 | 180 |
| #21MÜV Cannabis DispensaryMartin County | 3.0%11 of 350 squares | 7.6best 1 | 4.9 | 592 |
| #22Planet 13 Neighborhood Dispensary StuartMartin County | 2.8%10 of 350 squares | 9.6best 2 | 4.9 | 391 |
| #23CannaMDSt. Lucie County | 2.0%7 of 350 squares | 10.7best 2 | 4.9 | 113 |
| #24Trilogy Medicinal - Port St Lucie Medical Marijuana Doctor and Cannabis CardsSt. Lucie County | 2.0%7 of 350 squares | 10.8best 2 | 5.0 | 644 |
| #25GrowHealthy Dispensary - StuartStuart · Martin County | 1.9%7 of 350 squares | 10.8best 2 | 4.6 | 517 |
| #26Curaleaf Dispensary Fort PierceFort Pierce · St. Lucie County | 1.8%7 of 350 squares | 8.1best 1 | 4.6 | 805 |
| #27Mr. Smoke Port St LucieSt. Lucie County | 1.7%6 of 350 squares | 11.3best 1 | 4.8 | 576 |
| #28Miracle Leaf Medical Marijuana DoctorSt. Lucie County | 1.7%6 of 350 squares | 11.2best 1 | 4.8 | 133 |
| #29Med Leaf, LLCSt. Lucie County | 1.7%6 of 350 squares | 9.5best 2 | 4.2 | 30 |
| #30SMOKES SMOKE SHOPSt. Lucie County | 1.7%6 of 350 squares | 8.1best 2 | 4.9 | 339 |
| #31DoctorsRxSt. Lucie County | 1.1%4 of 350 squares | 10.2best 1 | 5.0 | 28 |
| #32SMOKIES SMOKE SHOPSt. Lucie County | 1.1%4 of 350 squares | 8.5best 1 | 4.8 | 280 |
| #33Hemp StationSt. Lucie County | 1.1%4 of 350 squares | 12.3best 2 | 4.5 | 33 |
| #34Medical Marijuana Treatment Clinics of FloridaSt. Lucie County | 1.1%4 of 350 squares | 10.9best 3 | 4.9 | 191 |
| #35Hemp HavenSt. Lucie County | 0.9%3 of 350 squares | 10.0best 3 | 5.0 | 55 |
| #36High ExpectationsSt. Lucie County | 0.9%3 of 350 squares | 11.4best 3 | 4.6 | 119 |
| #37Curaleaf Dispensary StuartStuart · Martin County | 0.8%3 of 350 squares | 11.3best 3 | 4.8 | 294 |
| #38The LeafMartin County | 0.6%2 of 350 squares | 12.1best 1 | 3.9 | 16 |
| #391ST SMOKE SHOPSt. Lucie County | 0.6%2 of 350 squares | 9.3best 2 | 4.8 | 47 |
| #40AYR Cannabis Dispensary StuartStuart · Martin County | 0.6%2 of 350 squares | 12.6best 3 | 4.9 | 634 |
| #41Trulieve Fort Pierce DispensarySt. Lucie County | 0.3%2 of 350 squares | 9.5best 3 | 4.6 | 819 |
| #42MMJ Health StuartMartin County | 0.3%1 of 350 squares | 12.8best 2 | 4.6 | 239 |
| #43ROYAL TOBACCO AND VAPESt. Lucie County | 0.3%1 of 350 squares | 11.7best 3 | 4.8 | 234 |
| #44CBD of Jensen BeachMartin County | 0.3%1 of 350 squares | 14.7best 3 | 4.8 | 45 |
| #45PSL SMOKE & VAPESt. Lucie County | 0.3%1 of 350 squares | 10.9best 3 | 4.4 | 61 |
| #46LEAFORIA SMOKE SHOPSt. Lucie County | 0.1%1 of 350 squares | 3.0best 3 | 4.9 | 22 |